Hepatocellular disease - Complete detail about Causes, Symptoms, Treatment & More

Are you want to know about hepatocellular disease? Finding detail about hepatocellular carcinoma? or looking detail for its treatment and causes? If you are really want to get an answer of such question in one place, here, we tried to provide you complete information about it.


What are Hepatocellular Diseases?
There are many types of hepatocellular diseases ranging from infections and cancers. The liver is one of the biggest organs in the body and is located just underneath the right rib cage. The liver is also the powerhouse/engine of the body and plays a vital role in many functions like metabolism and breakdown of many substances. Without the liver, survival would be impossible.

The liver can be affected by infections, drugs or toxic chemicals. The majority of liver problems are transient or acute in nature because the liver has great healing power. However, the chronic hepatocellular disease can last for a long time and present with a variety of symptoms. The classic symptoms of the diffuse hepatocellular liver disease include:
  •  Abdominal pain
  •  Distension of the abdomen
  •  Severe itching of skin
  •  Pale Stools
  •  Yellowish discoloration of the skin and eyes
  •  Intermittent blood in the stools
  •  Extreme fatigue
  •  Nausea Loss of appetite
Diagnosis of hepatocellular disorders includes:
  •  Blood tests which can measure liver function and presence of infections like hepatitis. The A blood tests can be used to follow the recovery after an infection or improvement in liver function.
  •  If any mass is suspected growing in the liver, then radiological tests like Ultrasound and CT scan are done
  •  Sometimes a liver biopsy may be required to determine the cause of liver problems. This small procedure can be done at the bedside using a small needle under local anesthesia.
The treatment of diffuse hepatocellular disease depends on the cause. While most cases can be treated with medications, some liver disorders may require surgery. If the liver is failing, the other option may be a liver transplant.

The best way to avoid liver disease is by preventing the problem in the first place. This means:
  •   Refraining from drinking excessive alcohol
  •   Avoiding promiscuous sexual behavior
  •   Avoiding use of intravenous drugs and sharing needles
  •   Avoiding tattoos and body piercing at unlicensed parlors
  •   Getting vaccinated with hepatitis B vaccine
  •   Using prescription medications wisely. Medications should not be mixed and not taken for prolonged time
  •   Avoiding contact with other people’s body fluids or blood. This also means avoiding sharing of personal care products.
Finally, one should eat healthily and exercise regularly. There are many causes of hepatocellular diseases, but by adopting a healthy lifestyle, most of the disorders can be prevented.


What Is Hepatocellular Carcinoma?

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is the most common cause of death in people with cirrhosis. It is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The cell(s) of origin are believed to be the hepatic stem cells, although this remains the subject of investigation. Tumors progress with local expansion, intrahepatic spread, and distant metastases.
HCC is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC.
The presentation of HCC has evolved significantly over the past few decades. Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis, using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements.
It's important to remember that you still have control over the decisions you make about your treatment and your life. Make sure you have people you can talk to about your plans, your fears, and your feelings. Ask your doctor about support groups, where you can meet people who know what you're going through.
Your doctor can help you understand your treatment options. Surgery, radiation, and chemotherapy are some of your choices.

Hepatocellular Carcinoma causes:

Here, are some list of causes of Hepatocellular Carcinoma as below:
Hepatitis B/C:

Hepatocellular cancer can start many years after you've had one of these liver infections. Both are passed through blood, such as when drug users share needles. Blood tests can show whether you have hepatitis B or C.



Cirrhosis:
This serious disease happens when liver cells are damaged and replaced with scar tissue. Many things can cause it: hepatitis B or C infection, alcohol drinking, certain drugs, and too much iron stored in the liver.

Heavy drinking: 
Having more than two alcoholic drinks a day for many years raises your risk of hepatocellular cancer. The more you drink, the higher your risk.

Obesity and diabetes: 
Both conditions raise your risk of liver cancer. Obesity can lead to nonalcoholic fatty liver disease, which can lead to hepatocellular carcinoma. The higher risk of diabetes may be due to high insulin levels in people with diabetes or from liver damage caused by the disease.

Iron storage disease:
This causes too much iron to be stored in the liver and other organs. People who have it may develop hepatocellular carcinoma.

Aflatoxin:
This harmful substance, which is made by certain types of mold on peanuts, corn, and other nuts and grains, can cause hepatocellular carcinoma. The U.S. has safety measures that limit aflatoxin in the food supply.

Treatment details:

Which treatment is best for you will depend on the size and location of your hepatocellular carcinoma, how well your liver is functioning, and your overall health.

Hepatocellular carcinoma treatments include:

Surgery: 
Surgery to remove the cancer and a margin of healthy tissue that surrounds it may be an option for people with early-stage liver cancers who have a normal liver function.

Liver transplant surgery: 
Surgery to remove the entire liver and replace it with a liver from a donor may be an option in otherwise healthy people whose liver cancer hasn't spread beyond the liver.

Destroying cancer cells with heat/cold: 
Ablation procedures to kill the cancer cells in the liver using extreme heat or cold may be recommended for people who can't undergo surgery. These procedures include radiofrequency ablation, cryoablation, and ablation using alcohol or microwaves.

chemotherapy or radiation directly to cancer cells:
Using a catheter that's passed through your blood vessels and into your liver, doctors can deliver chemotherapy drugs (chemoembolization) or tiny glass spheres containing radiation (radioembolization) directly to the cancer cells.

Targeted drug therapy:
Targeted drugs, such as sorafenib (Nexavar), may help slow the progression of the disease in people with advanced liver cancer.

Radiation therapy: 
Radiation therapy using energy from X-rays or protons may be recommended if surgery isn't an option. A specialized type of radiation therapy, called stereotactic body radiotherapy (SBRT), involves focusing many beams of radiation simultaneously at one point in your body.

Clinical trials:
Clinical trials give you a chance to try new liver cancer treatments. Ask your doctor whether you're eligible to participate in a clinical trial.

Hope you will get an answer of your question from our detailed guide about the hepatocellular disease and Hepatocellular carcinoma. If you want to ask us any query then tell us by commenting below.

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